Rough cocklebur
Xanthium strumarium L.
Rough cocklebur (Xanthium strumarium) is an annual daisy-family herb 50–120 cm tall whose hooked bur fruits cling to animal fur for dispersal; it is a medicine for rhinitis, hives and joint pain, but its seeds are highly toxic.
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Overview
Xanthium strumarium — rough cocklebur, cocklebur, clotbur or Noogoora burr — is an annual herb in the daisy family (Asteraceae), genus Xanthium, and the only species of that genus in Vietnam. The plant grows 50–120 cm tall, with grooved, hairy stems marked with purple spots, often purplish at the base. The alternate leaves are broadly ovate to triangular, 5–20 cm long and 4–16 cm wide, heart-shaped at the base, with irregular coarse teeth or shallowly three-lobed, on a petiole 3–10 cm long. The species is monoecious, with separate unisexual heads: the staminate (male) heads sit at the tips of the upper branches and the pistillate (female) heads in the lower leaf axils, wind-pollinated. The fruit is a bur-like achene, ovoid to spindle-shaped, 1–1.5 cm long, covered in stiff hooked spines and containing two seeds; the hooked bur clings to animal fur and clothing and is buoyant, so it disperses both on mammals and on water. Flowering and fruiting usually occur from July to October.
Updated by lebachungtdh@gmail.com · 10/12/2026
Rough cocklebur is widespread worldwide: some sources place its origin in southern Europe and Asia, while others (Flora of China, Flora of North America) consider it American and an early introduction to Eurasia; it now grows wild on waste ground, roadsides, river banks and cultivated land throughout Vietnam. It is a troublesome weed and a hazard to livestock: the seeds and seedlings contain carboxyatractyloside, an extremely toxic compound that damages the liver, so poisonings of pigs, cattle and sheep are not rare. In return, the fruit (known in Chinese medicine as cang er zi) and leaves are a traditional medicine in Vietnam and China: anti-allergic and anti-inflammatory, used for allergic rhinitis and foul nasal discharge, hives, boils, sores, eczema, joint and rheumatic pain, headache, toothache, dysentery and diarrhoea, at a decoction dose of 6–12 g per day. A decoction of the fruit is used as a mouthwash for toothache and applied for ringworm and tinea. Chemically the fruit contains sesquiterpene lactones (xanthinin, xanthumin, xanthatin), fatty oil, alkaloids and a blood-glucose-lowering glycoside, and the leaves accumulate iodine (about 200 micrograms per gram). Studies show that xanthatin and xanthinin have antibacterial, antifungal, anti-allergic, antipyretic, diuretic and sedative activity and are under further investigation for anti-inflammatory and anticancer effects.
Updated by lebachungtdh@gmail.com · 10/12/2026
Life cycle
From seed to productPlant
Annual herb 50–120 cm tall with grooved hairy stems, growing rapidly from seed on disturbed ground.
Leaf
Alternate leaves, broadly ovate–triangular, toothed or shallowly three-lobed.
Flower & bur
Monoecious, wind-pollinated flowers; the bur-like achene is covered in hooked spines and ripens in late summer–autumn.
Seed & dispersal
Each bur holds two seeds; the hooked spines cling to fur and clothing and the bur floats, aiding long-distance dispersal.
Distribution & origin
Share of recorded occurrences by region- East Asia (China, Japan, Korea)20%
- South & Southeast Asia (India, Vietnam, Thailand)25%
- Europe & the Mediterranean15%
- North America20%
- Africa, Australia & the Pacific20%
Chemical composition
Relative content in agarwood resin- Sesquiterpene lactones (xanthinin, xanthumin, xanthatin)Main actives: antibacterial, antifungal, anti-allergic30%
- Fatty oilIn fruit and seed15%
- AlkaloidsReported from the fruit15%
- Blood-glucose-lowering glycosideLowers blood glucose15%
- Iodine & mineralsLeaves ~200 micrograms iodine per g15%
- Flavonoids & phenolicsAntioxidant10%
Uses
- Traditional medicine (Vietnam & China): the fruit (cang er zi) and leaves are pungent and bitter, warm and mildly toxic; they dispel wind-damp, open the nose and are anti-allergic — used for allergic rhinitis and foul nasal discharge, hives, boils, sores, eczema, joint and rheumatic pain, headache, toothache and dysentery; decoction 6–12 g daily.
- External use: a decoction of the fruit is used as a mouthwash for toothache, and the fruit or leaves are pounded or boiled and applied or washed on ringworm, tinea, scabies, impetigo and itchy rashes.
- Modern pharmacology: xanthatin and xanthinin are studied for antibacterial, antifungal, anti-allergic, antipyretic, diuretic, sedative and glucose-lowering effects, and for potential anti-inflammatory and anticancer activity.
- Agriculture & ecology: a weed of disturbed ground, occasionally used as green manure or a botanical insecticide; on the other hand it is a crop weed that lowers yields and poisons livestock.
- Safety note: the seeds and seedlings contain carboxyatractyloside, which damages the liver — never eat them; use the medicine only at the correct dose, with caution (avoid) in pregnancy and liver disease; do not let livestock eat the seedlings.
Properties
- Form
- Annual herb 50–120 cm tall with grooved hairy stems
- Hallmark
- Broad ovate–triangular leaves; hooked spiny bur that clings to fur
- Pharmacology
- Anti-inflammatory, antimicrobial/antifungal, anti-allergic, antipyretic, diuretic, sedative
- Safety
- Seeds/seedlings toxic (carboxyatractyloside) — dose carefully, keep from livestock
Habitat & conservation
Rough cocklebur prefers sunny, dry to moist, nutrient-rich ground: waste places, roadsides, field edges, river banks, cultivated land, fallow and disturbed areas; from temperate to tropical regions. It grows rapidly from seed and reproduces strongly; the bur clings to animal fur and floats on water, so it spreads far.
Conservation
Rough cocklebur is a widespread species that is not threatened and is often regarded as a weed; it has not been assessed by the IUCN and is therefore listed as Not Evaluated (NE). Family Asteraceae, genus Xanthium. Values: medicine (cang er zi) and a subject of pharmacological research; on the other hand it harms agriculture and livestock.
References
- 1Xanthium strumarium L. — Plants of the World Online — POWO (Kew), 2026
- 2Xanthium strumarium L. — GBIF Backbone Taxonomy — GBIF, 2026
- 3Xanthium strumarium (rough cocklebur) — description, reproductive biology, toxicity — English Wikipedia, 2026
- 4Ké đầu ngựa (thương nhĩ) — mô tả, thành phần hoá học và công dụng — Vietnamese Wikipedia, 2026
- 5苍耳 — 形态、分布与药用(苍耳子) — Chinese Wikipedia, 2026
- 6Ảnh: NY State IPM Program at Cornell University (CC BY 2.0) — Wikimedia Commons, 2026
- 7Ảnh: Dinesh Valke (CC BY-SA 2.0); Vinayaraj (CC BY-SA 4.0) — Wikimedia Commons, 2026
